8F5W
Dihydropyrimidine Dehydrogenase (DPD) C671S Mutant Soaked with Dihydrothymine and NADPH Quasi-Anaerobically
Summary for 8F5W
Entry DOI | 10.2210/pdb8f5w/pdb |
Descriptor | Dihydropyrimidine dehydrogenase [NADP(+)], IRON/SULFUR CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | dihydropyrimidine dehydrogenase, protein, mutant, dihyrdothymine, nadph, flavoprotein |
Biological source | Sus scrofa (pig) |
Total number of polymer chains | 4 |
Total formula weight | 460429.08 |
Authors | Kaley, N.,Smith, M.,Forouzesh, D.,Liu, D.,Moran, G. (deposition date: 2022-11-15, release date: 2023-02-01, Last modification date: 2023-10-25) |
Primary citation | Smith, M.M.,Forouzesh, D.C.,Kaley, N.E.,Liu, D.,Moran, G.R. Mammalian dihydropyrimidine dehydrogenase: Added mechanistic details from transient-state analysis of charge transfer complexes. Arch.Biochem.Biophys., 736:109517-109517, 2023 Cited by PubMed: 36681231DOI: 10.1016/j.abb.2023.109517 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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