8F5J

human branched chain ketoacid dehydrogenase kinase in complex with inhibitors

8F5J の概要

• エントリーDOI: 10.2210/pdb8f5j/pdb
• 関連するPDBエントリー: 8F5F
• 分子名称: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: branched chain ketoacid dehydrogenase kinase, inhibitor, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44978.91

構造登録者

Liu, S.,Roth Flach, R.,Bollinger, E.,Filipski, K. (登録日: 2022-11-14, 公開日: 2023-07-05, 最終更新日: 2023-10-25)

• 主引用文献: Roth Flach, R.J.,Bollinger, E.,Reyes, A.R.,Laforest, B.,Kormos, B.L.,Liu, S.,Reese, M.R.,Martinez Alsina, L.A.,Buzon, L.,Zhang, Y.,Bechle, B.,Rosado, A.,Sahasrabudhe, P.V.,Knafels, J.,Bhattacharya, S.K.,Omoto, K.,Stansfield, J.C.,Hurley, L.D.,Song, L.,Luo, L.,Breitkopf, S.B.,Monetti, M.,Cunio, T.,Tierney, B.,Geoly, F.J.,Delmore, J.,Siddall, C.P.,Xue, L.,Yip, K.N.,Kalgutkar, A.S.,Miller, R.A.,Zhang, B.B.,Filipski, K.J.; Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels.; Nat Commun, 14:4812-4812, 2023; PubMed: 37558654; DOI: 10.1038/s41467-023-40536-y

実験手法

X-RAY DIFFRACTION (2.545 Å)