8F5F
human branched chain ketoacid dehydrogenase kinase in complex with inhibitors
Summary for 8F5F
Entry DOI | 10.2210/pdb8f5f/pdb |
Descriptor | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | branched chain ketoacid dehydrogenase kinase, inhibitor, signaling protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 90359.32 |
Authors | Liu, S.,Roth Flach, R.,Bollinger, E.,Filipski, K. (deposition date: 2022-11-14, release date: 2023-07-05, Last modification date: 2023-10-25) |
Primary citation | Roth Flach, R.J.,Bollinger, E.,Reyes, A.R.,Laforest, B.,Kormos, B.L.,Liu, S.,Reese, M.R.,Martinez Alsina, L.A.,Buzon, L.,Zhang, Y.,Bechle, B.,Rosado, A.,Sahasrabudhe, P.V.,Knafels, J.,Bhattacharya, S.K.,Omoto, K.,Stansfield, J.C.,Hurley, L.D.,Song, L.,Luo, L.,Breitkopf, S.B.,Monetti, M.,Cunio, T.,Tierney, B.,Geoly, F.J.,Delmore, J.,Siddall, C.P.,Xue, L.,Yip, K.N.,Kalgutkar, A.S.,Miller, R.A.,Zhang, B.B.,Filipski, K.J. Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels. Nat Commun, 14:4812-4812, 2023 Cited by PubMed: 37558654DOI: 10.1038/s41467-023-40536-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.149 Å) |
Structure validation
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