8F4U

Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with azelastine

Summary for 8F4U

• Entry DOI: 10.2210/pdb8f4u/pdb
• Descriptor: N-acetyltransferase Eis, 4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methylazepan-4-yl]phthalazin-1(2H)-one, GLYCEROL, ... (7 entities in total)
• Functional Keywords: drug resistance, inhibitor, acetylation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 1
• Total formula weight: 47029.70

Authors

Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2022-11-11, release date: 2023-02-08, Last modification date: 2024-05-22)

• Primary citation: Pang, A.H.,Green, K.D.,Punetha, A.,Thamban Chandrika, N.,Howard, K.C.,Garneau-Tsodikova, S.,Tsodikov, O.V.; Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.; Biochemistry, 62:710-721, 2023; PubMed: 36657084; DOI: 10.1021/acs.biochem.2c00658

Experimental method

X-RAY DIFFRACTION (1.91 Å)