8F4T

Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with proguanil

8F4T の概要

• エントリーDOI: 10.2210/pdb8f4t/pdb
• 分子名称: N-acetyltransferase Eis, N-(4-chlorophenyl)-N'-(propan-2-yl)triimidodicarbonic diamide, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: drug resistance, inhibitor, acetylation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46805.47

構造登録者

Punetha, A.,Pang, A.H.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2022-11-11, 公開日: 2023-02-01, 最終更新日: 2023-10-25)

• 主引用文献: Pang, A.H.,Green, K.D.,Punetha, A.,Thamban Chandrika, N.,Howard, K.C.,Garneau-Tsodikova, S.,Tsodikov, O.V.; Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.; Biochemistry, 62:710-721, 2023; PubMed: 36657084; DOI: 10.1021/acs.biochem.2c00658

実験手法

X-RAY DIFFRACTION (1.93 Å)