8F4A

Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with chlorhexidine

8F4A の概要

• エントリーDOI: 10.2210/pdb8f4a/pdb
• 分子名称: N-acetyltransferase Eis, GLYCEROL, 1-[6-[azanylidene-[[azanylidene-[[(4-chlorophenyl)amino]methyl]-$l^{4}-azanyl]methyl]-$l^{4}-azanyl]hexyl]-3-[~{N}-(4-chlorophenyl)carbamimidoyl]guanidine, ... (4 entities in total)
• 機能のキーワード: drug resistance, inhibitor, acetylation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46596.65

構造登録者

Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2022-11-10, 公開日: 2023-02-08, 最終更新日: 2023-10-25)

• 主引用文献: Pang, A.H.,Green, K.D.,Punetha, A.,Thamban Chandrika, N.,Howard, K.C.,Garneau-Tsodikova, S.,Tsodikov, O.V.; Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.; Biochemistry, 62:710-721, 2023; PubMed: 36657084; DOI: 10.1021/acs.biochem.2c00658

実験手法

X-RAY DIFFRACTION (2.41 Å)