8F30

LSD1-CoREST in complex with AW2, long soaking

8F30 の概要

• エントリーDOI: 10.2210/pdb8f30/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-{5-[3-([1,1'-biphenyl]-4-yl)propanoyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) (3 entities in total)
• 機能のキーワード: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112507.20

構造登録者

Caroli, J.,Mattevi, A. (登録日: 2022-11-09, 公開日: 2024-06-12)

• 主引用文献: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; to be published,

実験手法

X-RAY DIFFRACTION (3.1 Å)