8F2S

Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, pore-blocked state

8F2S の概要

• エントリーDOI: 10.2210/pdb8f2s/pdb
• EMDBエントリー: 28826
• 分子名称: Acetylcholine receptor subunit alpha, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, ... (13 entities in total)
• 機能のキーワード: acetylcholine receptor, nicotinic receptor, torpedo, cys-loop receptor, ion channel, muscle-type nicotinic receptor, transport protein-inhibitor complex, neuromuscular blocker, inhibitor, transport protein/inhibitor
• 由来する生物種: Tetronarce californica (Pacific electric ray); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 279324.99

構造登録者

Goswami, U.,Rahman, M.M.,Teng, J.,Hibbs, R.E. (登録日: 2022-11-08, 公開日: 2023-06-07, 最終更新日: 2023-06-14)

• 主引用文献: Goswami, U.,Rahman, M.M.,Teng, J.,Hibbs, R.E.; Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.; Nat Commun, 14:3169-3169, 2023; PubMed: 37264005; DOI: 10.1038/s41467-023-38827-5

実験手法

ELECTRON MICROSCOPY (2.9 Å)