8F1F

Structure of K48-linked tri-ubiquitin in complex with cyclic peptide

8F1F の概要

• エントリーDOI: 10.2210/pdb8f1f/pdb
• 分子名称: Ubiquitin, Non-proteinogenic cyclic peptide (inhibitor), GLYCEROL, ... (7 entities in total)
• 機能のキーワード: complex, therapeutic peptide, lys48-linked polyubiquitin, macrocyclic peptide, inhibitor of ubiquitin signaling, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 55291.38

構造登録者

Lubkowski, J.,Fushman, D.,Lemma, B. (登録日: 2022-11-05, 公開日: 2023-11-01, 最終更新日: 2023-11-15)

• 主引用文献: Lemma, B.,Zhang, D.,Vamisetti, G.B.,Wentz, B.G.,Suga, H.,Brik, A.,Lubkowski, J.,Fushman, D.; Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation.; Nat Commun, 14:7212-7212, 2023; PubMed: 37938554; DOI: 10.1038/s41467-023-43025-4

実験手法

X-RAY DIFFRACTION (1.85 Å)