8F10

Structure of the MDM2 P53 binding domain in complex with H102, an all-D Helicon Polypeptide

Summary for 8F10

Entry DOI	10.2210/pdb8f10/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, H102, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywords	e3 ligase, d-peptide, stapled peptide, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	13794.37
Authors	Li, K.,Callahan, A.J.,Travaline, T.L.,Tokareva, O.S.,Swiecicki, J.-M.,Verdine, G.L.,Pentelute, B.L.,McGee, J.H. (deposition date: 2022-11-04, release date: 2023-02-15, Last modification date: 2024-10-16)
Primary citation	Callahan, A.J.,Gandhesiri, S.,Travaline, T.L.,Lozano Salazar, L.,Hanna, S.,Lee, Y.-C.,Li, K.,Tokareva, O.S.,Swiecicki, J.-M.,Loas, A.,Verdine, G.L.,McGee, J.H.,Pentelute, B.L. Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023 Cited by DOI: 10.26434/chemrxiv-2023-x86xp PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.28 Å)

Structure validation