8F0P

Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305

8F0P の概要

• エントリーDOI: 10.2210/pdb8f0p/pdb
• EMDBエントリー: 28776
• 分子名称: Sodium channel protein PaFPC1,Sodium channel protein type 9 subunit alpha chimera, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: ion channel, small molecule, inhibitor, membrane protein-inhibitor complex, membrane protein/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 190809.97

構造登録者

Kschonsak, M.,Jao, C.C.,Arthur, C.P.,Rohou, A.L.,Bergeron, P.,Ortwine, D.,McKerall, S.J.,Hackos, D.H.,Deng, L.,Chen, J.,Sutherlin, D.,Dragovich, P.S.,Volgraf, M.,Wright, M.R.,Payandeh, J.,Ciferri, C.,Tellis, J.C. (登録日: 2022-11-03, 公開日: 2023-04-12)

• 主引用文献: Kschonsak, M.,Jao, C.C.,Arthur, C.P.,Rohou, A.L.,Bergeron, P.,Ortwine, D.F.,McKerrall, S.J.,Hackos, D.H.,Deng, L.,Chen, J.,Li, T.,Dragovich, P.S.,Volgraf, M.,Wright, M.R.,Payandeh, J.,Ciferri, C.,Tellis, J.C.; Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.; Elife, 12:-, 2023; PubMed: 36975198; DOI: 10.7554/eLife.84151

実験手法

ELECTRON MICROSCOPY (2.2 Å)