8F0F
HIV-1 wild type protease with GRL-110-19A, a chloroacetamide derivative based on Darunavir as P2' group
Summary for 8F0F
Entry DOI | 10.2210/pdb8f0f/pdb |
Related | 2IEN 6U7O |
Descriptor | Protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | aspartic acid protease, hiv-1 protease, darunavir, a chloroacetamide derivative inhibitor, antiviral protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22326.94 |
Authors | Wang, Y.-F.,Agniswamy, J.,Ghosh, A.K.,Weber, I.T. (deposition date: 2022-11-02, release date: 2023-02-15, Last modification date: 2023-10-25) |
Primary citation | Ghosh, A.K.,Shahabi, D.,Kipfmiller, M.,Ghosh, A.K.,Johnson, M.,Wang, Y.F.,Agniswamy, J.,Amano, M.,Weber, I.T.,Mitsuya, H. Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. Bioorg.Med.Chem.Lett., 83:129168-129168, 2023 Cited by PubMed: 36738797DOI: 10.1016/j.bmcl.2023.129168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.29 Å) |
Structure validation
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