8EZ1

Human Ornithine Aminotransferase (hOAT) co-crystallized with its inactivator 3-Amino-4-fluorocyclopentenecarboxylic Acid

8EZ1 の概要

• エントリーDOI: 10.2210/pdb8ez1/pdb
• 分子名称: Ornithine aminotransferase, mitochondrial, (3E,4E)-4-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-iminocyclopent-1-ene-1-carboxylic acid, (1R,3S,4Z)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: hoat, oat, inactivator, 3-amino-4-fluorocyclopentenecarboxylic acid, covalent modification, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 135647.75

構造登録者

Butrin, A.,Shen, S.,Silverman, R.,Liu, D. (登録日: 2022-10-30, 公開日: 2023-02-22, 最終更新日: 2024-03-13)

• 主引用文献: Shen, S.,Butrin, A.,Beaupre, B.A.,Ferreira, G.M.,Doubleday, P.F.,Grass, D.H.,Zhu, W.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B.; Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid.; Molecules, 28:-, 2023; PubMed: 36770800; DOI: 10.3390/molecules28031133

実験手法

X-RAY DIFFRACTION (1.91 Å)