8EXX

Herpes simplex virus 1 polymerase holoenzyme bound to DNA and foscarnet (pre-translocation state)

Summary for 8EXX

Entry DOI	10.2210/pdb8exx/pdb
EMDB information	28663 28664 42887 42888 42889 42890 42891
Descriptor	DNA polymerase, DNA polymerase processivity factor, Primer DNA (32-MER), ... (6 entities in total)
Functional Keywords	herpes simplex virus, replication, dna polymerase holoenzyme, ul30, ul42, pre-translocation, foscarnet, viral protein, viral protein-dna complex, viral protein/dna
Biological source	Human alphaherpesvirus 1 strain KOS More
Total number of polymer chains	4
Total formula weight	195249.60
Authors	Pan, J.,Abraham, J.,Coen, D.M.,Shankar, S.,Yang, P.,Hogle, J. (deposition date: 2022-10-26, release date: 2024-09-04)
Primary citation	Shankar, S.,Pan, J.,Yang, P.,Bian, Y.,Oroszlan, G.,Yu, Z.,Mukherjee, P.,Filman, D.J.,Hogle, J.,Shekhar, M.,Coen, D.M.,Abraham, J. Viral DNA polymerase structures reveal mechanisms for drug selectivity Cell(Cambridge,Mass.), 2024 Cited by DOI: 10.1016/j.cell.2024.07.048 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation