8EVF
HUMAN DNA POLYMERASE ETA EXTENSION COMPLEX WITH AN INCOMING DCTP
Summary for 8EVF
Entry DOI | 10.2210/pdb8evf/pdb |
Descriptor | DNA polymerase eta, DNA 5'-D(P*TP*GP*(MO1)P*TP*GP*AP*CP*GP*CP*T-3', DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*G)-3'), ... (6 entities in total) |
Functional Keywords | dna damage, dna polymerase, lesion bypass, y-family polymerase, translesion dna synthesis (tls), dna binding protein, transferase-dna complex, replication, transferase/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 55347.08 |
Authors | Pallan, P.S.,Egli, M. (deposition date: 2022-10-20, release date: 2023-08-02, Last modification date: 2023-08-30) |
Primary citation | Richie-Jannetta, R.,Pallan, P.,Kingsley, P.J.,Kamdar, N.,Egli, M.,Marnett, L.J. The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta. J.Biol.Chem., 299:105067-105067, 2023 Cited by PubMed: 37468099DOI: 10.1016/j.jbc.2023.105067 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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