8ER0

X-ray crystal structure of Tet(X6) bound to anhydrotetracycline

Summary for 8ER0

• Entry DOI: 10.2210/pdb8er0/pdb
• Descriptor: Flavin-dependent monooxygenase, 5A,6-ANHYDROTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: tetracycline destructase, fad-linked reductases, flavoprotein, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Chryseobacterium oncorhynchi
• Total number of polymer chains: 2
• Total formula weight: 93719.40

Authors

Kumar, H.,Tolia, N.H. (deposition date: 2022-10-11, release date: 2023-04-26, Last modification date: 2023-10-25)

• Primary citation: Kumar, H.,Williford, E.E.,Blake, K.S.,Virgin-Downey, B.,Dantas, G.,Wencewicz, T.A.,Tolia, N.H.; Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.; Commun Biol, 6:423-423, 2023; PubMed: 37062778; DOI: 10.1038/s42003-023-04792-4

Experimental method

X-RAY DIFFRACTION (2.2 Å)