8EQC

Crystal structure of human anti-N1 neuraminidase 3H03 Fab

Summary for 8EQC

• Entry DOI: 10.2210/pdb8eqc/pdb
• Related: 8e6j
• Descriptor: 3H03 Fab light chain, 3H03 Fab heavy chain, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: antibody, neuraminidase, h1n1, broad protection, pandemic, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 95787.35

Authors

Zhu, X.,Wilson, I.A. (deposition date: 2022-10-07, release date: 2023-08-09, Last modification date: 2023-08-23)

• Primary citation: Hansen, L.,McMahon, M.,Turner, H.L.,Zhu, X.,Turner, J.S.,Ozorowski, G.,Stadlbauer, D.,Vahokoski, J.,Schmitz, A.J.,Rizk, A.A.,Alsoussi, W.B.,Strohmeier, S.,Yu, W.,Choreno-Parra, J.A.,Jimenez-Alvarez, L.,Cruz-Lagunas, A.,Zuniga, J.,Mudd, P.A.,Cox, R.J.,Wilson, I.A.,Ward, A.B.,Ellebedy, A.H.,Krammer, F.; Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo.; Immunity, 56:1927-, 2023; PubMed: 37506693; DOI: 10.1016/j.immuni.2023.07.004

Experimental method

X-RAY DIFFRACTION (2.2 Å)