8EPK

Complex of anticoagulant RNA aptamer and human coagulation factor IXa (S195A)

Summary for 8EPK

• Entry DOI: 10.2210/pdb8epk/pdb
• Related: 8EPC
• Descriptor: Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, RNA (31-MER), ... (6 entities in total)
• Functional Keywords: coagulation factor ix, rna aptamer, inhibitor, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 87253.61

Authors

Kolyadko, V.N.,Krishnaswamy, S. (deposition date: 2022-10-05, release date: 2024-07-03)

• Primary citation: Kolyadko, V.N.,Layzer, J.M.,Perry, K.,Sullenger, B.A.,Krishnaswamy, S.; Allosteric Control of Coagulation Factor IXa via Its Exosite II Regulates Blood Clotting; Proc.Natl.Acad.Sci.USA, 2024; DOI: 10.1073/pnas.2401136121

Experimental method

X-RAY DIFFRACTION (2.65 Å)