8EPH

Crystal structure of human coagulation factor IXa (S195A), apo-form, DES-GLA

8EPH の概要

• エントリーDOI: 10.2210/pdb8eph/pdb
• 分子名称: Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, alpha-L-fucopyranose, ... (5 entities in total)
• 機能のキーワード: coagulation factor ix, apo form, hydrolase, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 75471.61

構造登録者

Kolyadko, V.N.,Krishnaswamy, S. (登録日: 2022-10-05, 公開日: 2024-07-03, 最終更新日: 2024-07-24)

• 主引用文献: Kolyadko, V.N.,Layzer, J.M.,Perry, K.,Sullenger, B.A.,Krishnaswamy, S.; An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa.; Proc.Natl.Acad.Sci.USA, 121:e2401136121-e2401136121, 2024; PubMed: 38985762; DOI: 10.1073/pnas.2401136121

実験手法

X-RAY DIFFRACTION (1.88 Å)