8EOH
crystal structure of human Cytochrome P450 8B1 in complex with a C12-Pyridine Containing Steroid
Summary for 8EOH
| Entry DOI | 10.2210/pdb8eoh/pdb |
| Descriptor | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, 12-(pyridin-3-yl)-8alpha,10alpha,13alpha,14beta-androsta-4,11-diene-3,17-dione, ... (4 entities in total) |
| Functional Keywords | monooxygenase, sterol 12-hydroxylase, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 58107.70 |
| Authors | Liu, J.,Scott, E.E. (deposition date: 2022-10-03, release date: 2023-08-02, Last modification date: 2024-05-22) |
| Primary citation | Liu, J.,Offei, S.D.,Yoshimoto, F.K.,Scott, E.E. Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281. J.Biol.Chem., 299:103032-103032, 2023 Cited by PubMed: 36806682DOI: 10.1016/j.jbc.2023.103032 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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