8EO7

Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution

Summary for 8EO7

• Entry DOI: 10.2210/pdb8eo7/pdb
• Descriptor: beta-lactamase (2 entities in total)
• Functional Keywords: beta-lactamase precursor, environmental resistome, soil metagenome, mutant, antimicrobial protein
• Biological source: uncultured soil bacterium
• Total number of polymer chains: 2
• Total formula weight: 61944.69

Authors

Power, P.,D'Amico Gonzalez, G.,Centron, D.,Gutkind, G.,Handelsman, J.,Klinke, S. (deposition date: 2022-10-02, release date: 2023-10-04)

• Primary citation: D'Amico Gonzalez, G.,Handelsman, J.,Centron, D.,Gutkind, G.,Klinke, S.,Power, P.; Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions; to be published,

Experimental method

X-RAY DIFFRACTION (2.15 Å)