8EO7
Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution
Summary for 8EO7
Entry DOI | 10.2210/pdb8eo7/pdb |
Descriptor | beta-lactamase (2 entities in total) |
Functional Keywords | beta-lactamase precursor, environmental resistome, soil metagenome, mutant, antimicrobial protein |
Biological source | uncultured soil bacterium |
Total number of polymer chains | 2 |
Total formula weight | 61944.69 |
Authors | Power, P.,D'Amico Gonzalez, G.,Centron, D.,Gutkind, G.,Handelsman, J.,Klinke, S. (deposition date: 2022-10-02, release date: 2023-10-04) |
Primary citation | D'Amico Gonzalez, G.,Handelsman, J.,Centron, D.,Gutkind, G.,Klinke, S.,Power, P. Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions to be published, |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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