8EO5
Crystal structure of the class A beta-lactamase precursor LRA-5 from an Alaskan soil metagenome at 1.8 Angstrom resolution
Summary for 8EO5
Entry DOI | 10.2210/pdb8eo5/pdb |
Descriptor | LRA-5, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total) |
Functional Keywords | beta-lactamase precursor, environmental resistome, soil metagenome, antimicrobial protein |
Biological source | uncultured soil bacterium |
Total number of polymer chains | 2 |
Total formula weight | 62076.96 |
Authors | Power, P.,D'Amico Gonzalez, G.,Centron, D.,Gutkind, G.,Handelsman, J.,Klinke, S. (deposition date: 2022-10-02, release date: 2023-09-06) |
Primary citation | D'Amico Gonzalez, G.,Handelsman, J.,Centron, D.,Gutkind, G.,Klinke, S.,Power, P. Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions to be published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)