8EME

EGFR(T790M/V948R) in complex with ZNL-0056

Summary for 8EME

• Entry DOI: 10.2210/pdb8eme/pdb
• Descriptor: Epidermal growth factor receptor, N-{7-methyl-1-[(3S)-1-(prop-2-enoyl)azepan-3-yl]-1H-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide (2 entities in total)
• Functional Keywords: egfr, kinase, covalent, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 75926.77

Authors

Beyett, T.S.,Eck, M.J. (deposition date: 2022-09-27, release date: 2023-10-18, Last modification date: 2024-03-06)

• Primary citation: Li, Z.,Jiang, J.,Ficarro, S.B.,Beyett, T.S.,To, C.,Tavares, I.,Zhu, Y.,Li, J.,Eck, M.J.,Janne, P.A.,Marto, J.A.,Zhang, T.,Che, J.,Gray, N.S.; Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality; Acs Cent.Sci., 2024; DOI: 10.1021/acscentsci.3c01245

Experimental method

X-RAY DIFFRACTION (3.32 Å)