8EME
EGFR(T790M/V948R) in complex with ZNL-0056
Summary for 8EME
Entry DOI | 10.2210/pdb8eme/pdb |
Descriptor | Epidermal growth factor receptor, N-{7-methyl-1-[(3S)-1-(prop-2-enoyl)azepan-3-yl]-1H-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide (2 entities in total) |
Functional Keywords | egfr, kinase, covalent, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 75926.77 |
Authors | Beyett, T.S.,Eck, M.J. (deposition date: 2022-09-27, release date: 2023-10-18, Last modification date: 2024-07-10) |
Primary citation | Li, Z.,Jiang, J.,Ficarro, S.B.,Beyett, T.S.,To, C.,Tavares, I.,Zhu, Y.,Li, J.,Eck, M.J.,Janne, P.A.,Marto, J.A.,Zhang, T.,Che, J.,Gray, N.S. Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality. Acs Cent.Sci., 10:1156-1166, 2024 Cited by PubMed: 38947214DOI: 10.1021/acscentsci.3c01245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.32 Å) |
Structure validation
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