8EM4
Cryo-EM structure of LRP2 at pH 7.5
Summary for 8EM4
Entry DOI | 10.2210/pdb8em4/pdb |
EMDB information | 28233 28241 28242 28243 28250 |
Descriptor | Low-density lipoprotein receptor-related protein 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... (5 entities in total) |
Functional Keywords | lrp2, megalin, gp330, endocytosis, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 2 |
Total formula weight | 1063617.07 |
Authors | Beenken, A.,Cerutti, G.,Brasch, J.,Fitzpatrick, A.W.,Barasch, J.,Shapiro, L. (deposition date: 2022-09-26, release date: 2023-02-08, Last modification date: 2023-03-08) |
Primary citation | Beenken, A.,Cerutti, G.,Brasch, J.,Guo, Y.,Sheng, Z.,Erdjument-Bromage, H.,Aziz, Z.,Robbins-Juarez, S.Y.,Chavez, E.Y.,Ahlsen, G.,Katsamba, P.S.,Neubert, T.A.,Fitzpatrick, A.W.P.,Barasch, J.,Shapiro, L. Structures of LRP2 reveal a molecular machine for endocytosis. Cell, 186:821-, 2023 Cited by PubMed: 36750096DOI: 10.1016/j.cell.2023.01.016 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.83 Å) |
Structure validation
Download full validation report