8ELP

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-240

8ELP の概要

• エントリーDOI: 10.2210/pdb8elp/pdb
• 分子名称: Spike protein S1, Nanobody Nb-C4-240, CC12.1 Fab heavy chain, ... (5 entities in total)
• 機能のキーワード: synthetic, nanobody, sars-cov-2, coronavirus, neutralization, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 85791.44

構造登録者

Liu, H.,Wilson, I.A. (登録日: 2022-09-26, 公開日: 2023-07-05, 最終更新日: 2023-10-25)

• 主引用文献: Misson Mindrebo, L.,Liu, H.,Ozorowski, G.,Tran, Q.,Woehl, J.,Khalek, I.,Smith, J.M.,Barman, S.,Zhao, F.,Keating, C.,Limbo, O.,Verma, M.,Liu, J.,Stanfield, R.L.,Zhu, X.,Turner, H.L.,Sok, D.,Huang, P.S.,Burton, D.R.,Ward, A.B.,Wilson, I.A.,Jardine, J.G.; Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.; Proc.Natl.Acad.Sci.USA, 120:e2216612120-e2216612120, 2023; PubMed: 37276407; DOI: 10.1073/pnas.2216612120

実験手法

X-RAY DIFFRACTION (2.83 Å)