8ELO
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-225
Summary for 8ELO
Entry DOI | 10.2210/pdb8elo/pdb |
Descriptor | Spike protein S1, Nanobody Nb-C4-225, CC12.1 Fab heavy chain, ... (5 entities in total) |
Functional Keywords | synthetic, nanobody, sars-cov-2, coronavirus, neutralization, immune system, viral protein-immune system complex, viral protein/immune system |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 4 |
Total formula weight | 85524.12 |
Authors | Liu, H.,Wilson, I.A. (deposition date: 2022-09-26, release date: 2023-07-05, Last modification date: 2023-10-25) |
Primary citation | Misson Mindrebo, L.,Liu, H.,Ozorowski, G.,Tran, Q.,Woehl, J.,Khalek, I.,Smith, J.M.,Barman, S.,Zhao, F.,Keating, C.,Limbo, O.,Verma, M.,Liu, J.,Stanfield, R.L.,Zhu, X.,Turner, H.L.,Sok, D.,Huang, P.S.,Burton, D.R.,Ward, A.B.,Wilson, I.A.,Jardine, J.G. Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins. Proc.Natl.Acad.Sci.USA, 120:e2216612120-e2216612120, 2023 Cited by PubMed: 37276407DOI: 10.1073/pnas.2216612120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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