8ELC
Human JNK2 bound to covalent inhibitor YL2056
8ELC の概要
エントリーDOI | 10.2210/pdb8elc/pdb |
分子名称 | Mitogen-activated protein kinase 9, 4-(dimethylamino)-N-{4-[(3S)-3-({4-[(8R)-2-phenylpyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amino)pyrrolidine-1-carbonyl]phenyl}butanamide (3 entities in total) |
機能のキーワード | jnk2, yliu2056, kinase inhibitor, structure-based drug design, transferase, transferase-inhibitor complex, cell cycle, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 48783.67 |
構造登録者 | |
主引用文献 | Lu, W.,Liu, Y.,Gao, Y.,Geng, Q.,Gurbani, D.,Li, L.,Ficarro, S.B.,Meyer, C.J.,Sinha, D.,You, I.,Tse, J.,He, Z.,Ji, W.,Che, J.,Kim, A.Y.,Yu, T.,Wen, K.,Anderson, K.C.,Marto, J.A.,Westover, K.D.,Zhang, T.,Gray, N.S. Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66:3356-3371, 2023 Cited by PubMed: 36826833DOI: 10.1021/acs.jmedchem.2c01834 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.072 Å) |
構造検証レポート
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