8EF8

Staphylococcus aureus ClpP Y63W in complex with compound 3471

Summary for 8EF8

• Entry DOI: 10.2210/pdb8ef8/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, (5S,6S,9aS)-N-[(4-fluorophenyl)methyl]-6-methyl-8-[(naphthalen-1-yl)methyl]-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide, ... (4 entities in total)
• Functional Keywords: clpp, cytosolic protein
• Biological source: Staphylococcus aureus subsp. aureus NCTC 8325
• Total number of polymer chains: 14
• Total formula weight: 324178.85

Authors

Lee, R.E.,Griffith, E.C. (deposition date: 2022-09-08, release date: 2023-07-19, Last modification date: 2023-10-25)

• Primary citation: Singh, A.C.,Zhao, Y.,Griffith, E.C.,Tangallapally, R.,Jarret, M.W.,Lee, R.E.; Development of a high throughput and site specific, fluorescent polarization assay to screen for activators of Caseinolytic Protease P leads to the discovery of synthetically tractable new activator class; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.17 Å)