8EDH

Identification of a class of WNK isoform-specific inhibitors through high-throughput screening

8EDH の概要

• エントリーDOI: 10.2210/pdb8edh/pdb
• 分子名称: Serine/threonine-protein kinase WNK3, ethyl 1-(5,7-dimethoxy-4-methylquinolin-2-yl)piperidine-4-carboxylate (3 entities in total)
• 機能のキーワード: inhibitor, wnk3, kinase, complex, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67634.29

構造登録者

Akella, R.,Goldsmith, E.J. (登録日: 2022-09-04, 公開日: 2023-03-01, 最終更新日: 2023-10-25)

• 主引用文献: Chlebowicz, J.,Akella, R.,Humphreys, J.M.,He, H.,Kannangara, A.R.,Wei, S.,Posner, B.,Goldsmith, E.J.; Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening.; Drug Des Devel Ther, 17:93-105, 2023; PubMed: 36712947; DOI: 10.2147/DDDT.S389461

実験手法

X-RAY DIFFRACTION (3.111 Å)