8EAD

Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-177

8EAD の概要

• エントリーDOI: 10.2210/pdb8ead/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-{2-chloro-5-[(5-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]anilino}pyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide, ... (4 entities in total)
• 機能のキーワード: bet, jak2, dual brd-kinase inhibitor, gene regulation
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15782.64

構造登録者

Karim, M.R.,Schonbrunn, E. (登録日: 2022-08-29, 公開日: 2022-09-07, 最終更新日: 2023-10-18)

• 主引用文献: Karim, M.R.,Schonbrunn, E.; Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-177; To Be Published,

実験手法

X-RAY DIFFRACTION (1.65 Å)