8E9Z
CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo
Summary for 8E9Z
Entry DOI | 10.2210/pdb8e9z/pdb |
EMDB information | 27969 |
Descriptor | Muscarinic acetylcholine receptor M3, miniGq, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | gpcr, ixo, active state, membrane protein, hm3r, iperoxo |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 166074.70 |
Authors | Zhang, S.,Fay, J.F.,Roth, B.L. (deposition date: 2022-08-27, release date: 2022-11-30, Last modification date: 2022-12-21) |
Primary citation | Zhang, S.,Gumpper, R.H.,Huang, X.P.,Liu, Y.,Krumm, B.E.,Cao, C.,Fay, J.F.,Roth, B.L. Molecular basis for selective activation of DREADD-based chemogenetics. Nature, 612:354-362, 2022 Cited by PubMed: 36450989DOI: 10.1038/s41586-022-05489-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.69 Å) |
Structure validation
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