8E7H

Cryo-EM structure of cardiac amyloid fibril from a wild-type amyloidosis patient

Summary for 8E7H

• Entry DOI: 10.2210/pdb8e7h/pdb
• EMDB information: 26691
• Descriptor: Transthyretin (1 entity in total)
• Functional Keywords: transthyretin, amyloidosis, systemic amyloidosis, attr, cardiac, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 5
• Total formula weight: 79524.92

Authors

Nguyen, B.A.,Saelices, L. (deposition date: 2022-08-23, release date: 2023-08-30, Last modification date: 2025-03-12)

• Primary citation: Nguyen, B.A.,Singh, V.,Afrin, S.,Singh, P.,Pekala, M.,Ahmed, Y.,Pedretti, R.,Canepa, J.,Lemoff, A.,Kluve-Beckerman, B.,Wydorski, P.M.,Chhapra, F.,Saelices, L.; Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis; Commun Biol, 7:905-, 2024; DOI: 10.1038/s42003-024-06588-6

Experimental method

ELECTRON MICROSCOPY (3.7 Å)