8E7E
Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient
Summary for 8E7E
Entry DOI | 10.2210/pdb8e7e/pdb |
EMDB information | 26685 |
Descriptor | Transthyretin (1 entity in total) |
Functional Keywords | transthyretin, amyloidosis, systemic amyloidosis, attr, cardiac, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 5 |
Total formula weight | 79394.51 |
Authors | Nguyen, B.A.,Singh, V.,Afrin, S.,Saelices, L. (deposition date: 2022-08-23, release date: 2023-08-30, Last modification date: 2024-05-01) |
Primary citation | Nguyen, B.A.,Singh, V.,Afrin, S.,Yakubovska, A.,Wang, L.,Ahmed, Y.,Pedretti, R.,Fernandez-Ramirez, M.D.C.,Singh, P.,Pekala, M.,Cabrera Hernandez, L.O.,Kumar, S.,Lemoff, A.,Gonzalez-Prieto, R.,Sawaya, M.R.,Eisenberg, D.S.,Benson, M.D.,Saelices, L. Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15:581-581, 2024 Cited by PubMed: 38233397DOI: 10.1038/s41467-024-44820-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.61 Å) |
Structure validation
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