8E7B
Crystal structure of the p53 (Y107H) core domain monoclinic P form
Summary for 8E7B
Entry DOI | 10.2210/pdb8e7b/pdb |
Descriptor | Cellular tumor antigen p53, ZINC ION (3 entities in total) |
Functional Keywords | dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 49516.91 |
Authors | Lovell, S.,Liu, L.,Battaile, K.P.,Miller, S.,Karanicolas, J. (deposition date: 2022-08-23, release date: 2023-05-17, Last modification date: 2023-10-25) |
Primary citation | Indeglia, A.,Leung, J.C.,Miller, S.A.,Leu, J.I.,Dougherty, J.F.,Clarke, N.L.,Kirven, N.A.,Shao, C.,Ke, L.,Lovell, S.,Barnoud, T.,Lu, D.Y.,Lin, C.,Kannan, T.,Battaile, K.P.,Yang, T.H.L.,Batista Oliva, I.,Claiborne, D.T.,Vogel, P.,Liu, L.,Liu, Q.,Nefedova, Y.,Cassel, J.,Auslander, N.,Kossenkov, A.V.,Karanicolas, J.,Murphy, M.E. An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression. Cancer Discov, 13:1696-1719, 2023 Cited by PubMed: 37140445DOI: 10.1158/2159-8290.CD-22-1315 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report