8E76
Cryo-EM structure of Apo form ME3
Summary for 8E76
Entry DOI | 10.2210/pdb8e76/pdb |
EMDB information | 27936 |
Descriptor | NADP-dependent malic enzyme, mitochondrial (1 entity in total) |
Functional Keywords | me1, me2, me3, nad(p)-dependent malic enzymes, integrated structural techniques, crystal structures, cryo-em structures, drug discovery, allosteric mechanism, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 268605.00 |
Authors | Yu, X.,Grell, T.A.J.,Shaffer, P.L.,Steele, R.,Sharma, S.,Thompson, A.A.,Tresadern, G.,Ortiz-Meoz, R.F.,Mason, M.,Gomez-Tamayo, J.C.,Riley, D.,Wagner, M.V.,Wadia, J. (deposition date: 2022-08-23, release date: 2023-02-08, Last modification date: 2024-06-19) |
Primary citation | Grell, T.A.J.,Mason, M.,Thompson, A.A.,Gomez-Tamayo, J.C.,Riley, D.,Wagner, M.V.,Steele, R.,Ortiz-Meoz, R.F.,Wadia, J.,Shaffer, P.L.,Tresadern, G.,Sharma, S.,Yu, X. Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer. Heliyon, 8:e12392-e12392, 2022 Cited by PubMed: 36590518DOI: 10.1016/j.heliyon.2022.e12392 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.51 Å) |
Structure validation
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