8E4L

The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2

8E4L の概要

• エントリーDOI: 10.2210/pdb8e4l/pdb
• EMDBエントリー: 27891
• 分子名称: Transient receptor potential cation channel subfamily M member 8, CALCIUM ION, 3-isothiocyanatoprop-1-ene, ... (5 entities in total)
• 機能のキーワード: trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 530778.02

構造登録者

Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (登録日: 2022-08-18, 公開日: 2022-10-26)

• 主引用文献: Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y.; Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.; Science, 378:eadd1268-eadd1268, 2022; PubMed: 36227998; DOI: 10.1126/science.add1268

実験手法

ELECTRON MICROSCOPY (3.32 Å)