8E4A
Pseudomonas LpxC in complex with LPC-233
Summary for 8E4A
Entry DOI | 10.2210/pdb8e4a/pdb |
Descriptor | UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, 4-(4-cyclopropylbuta-1,3-diyn-1-yl)-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide, ... (4 entities in total) |
Functional Keywords | lpxc, lipid a, biosynthetic protein |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 33588.38 |
Authors | |
Primary citation | Zhao, J.,Cochrane, C.S.,Najeeb, J.,Gooden, D.,Sciandra, C.,Fan, P.,Lemaitre, N.,Newns, K.,Nicholas, R.A.,Guan, Z.,Thaden, J.T.,Fowler Jr., V.G.,Spasojevic, I.,Sebbane, F.,Toone, E.J.,Duncan, C.,Gammans, R.,Zhou, P. Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Sci Transl Med, 15:eadf5668-eadf5668, 2023 Cited by PubMed: 37556556DOI: 10.1126/scitranslmed.adf5668 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.034 Å) |
Structure validation
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