8E17

BRD4-D1 in complex with BET inhibitor

8E17 の概要

• エントリーDOI: 10.2210/pdb8e17/pdb
• 関連するPDBエントリー: 8DYR
• 分子名称: Bromodomain-containing protein 4, (4P,6M)-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-4-[5-(methanesulfonyl)-2-methoxyphenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, bet inhibitor, brd4, pet radiotracer, solid tumor imaging, gene regulation-inhibitor complex, gene regulation/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15617.94

構造登録者

Gorman, M.A.,Fitzgerald, C.G.D.,White, J.M.,Parker, M.W. (登録日: 2022-08-09, 公開日: 2023-03-29, 最終更新日: 2023-10-25)

• 主引用文献: Dickmann, C.G.F.,McDonald, A.F.,Huynh, N.,Rigopoulos, A.,Liu, Z.,Guo, N.,Osellame, L.D.,Gorman, M.A.,Parker, M.W.,Gan, H.K.,Scott, A.M.,Ackermann, U.,Burvenich, I.J.G.,White, J.M.; Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography.; Chem.Commun.(Camb.), 59:3126-3129, 2023; PubMed: 36809538; DOI: 10.1039/d2cc04813b

実験手法

X-RAY DIFFRACTION (1.47 Å)