8DYI
IL17A homodimer bound to Compound 5
Summary for 8DYI
Entry DOI | 10.2210/pdb8dyi/pdb |
Related | 8DYF 8DYG 8DYH |
Descriptor | Interleukin-17A, (5P)-5-[5-(benzylamino)pyridin-3-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-amine (3 entities in total) |
Functional Keywords | dimer, fragment, inhibitor, antagonist, cytokine |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 29931.74 |
Authors | Argiriadi, M.A.,Goedken, E.R. (deposition date: 2022-08-04, release date: 2022-09-07, Last modification date: 2023-10-18) |
Primary citation | Goedken, E.R.,Argiriadi, M.A.,Dietrich, J.D.,Petros, A.M.,Krishnan, N.,Panchal, S.C.,Qiu, W.,Wu, H.,Zhu, H.,Adams, A.M.,Bodelle, P.M.,Goguen, L.,Richardson, P.L.,Slivka, P.F.,Srikumaran, M.,Upadhyay, A.K.,Wu, B.,Judge, R.A.,Vasudevan, A.,Gopalakrishnan, S.M.,Cox, P.B.,Stoll, V.S.,Sun, C. Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12:14561-14561, 2022 Cited by PubMed: 36028520DOI: 10.1038/s41598-022-18760-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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