8DYH

IL17A homodimer bound to Compound 6

8DYH の概要

• エントリーDOI: 10.2210/pdb8dyh/pdb
• 分子名称: Interleukin-17A, (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: dimer, fragment, inhibitor, antagonist, cytokine
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29858.43

構造登録者

Argiriadi, M.A.,Goedken, E.R. (登録日: 2022-08-04, 公開日: 2022-09-07, 最終更新日: 2023-10-18)

• 主引用文献: Goedken, E.R.,Argiriadi, M.A.,Dietrich, J.D.,Petros, A.M.,Krishnan, N.,Panchal, S.C.,Qiu, W.,Wu, H.,Zhu, H.,Adams, A.M.,Bodelle, P.M.,Goguen, L.,Richardson, P.L.,Slivka, P.F.,Srikumaran, M.,Upadhyay, A.K.,Wu, B.,Judge, R.A.,Vasudevan, A.,Gopalakrishnan, S.M.,Cox, P.B.,Stoll, V.S.,Sun, C.; Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.; Sci Rep, 12:14561-14561, 2022; PubMed: 36028520; DOI: 10.1038/s41598-022-18760-1

実験手法

X-RAY DIFFRACTION (1.94 Å)