8DYF
IL17A homodimer bound to Compound 10
Summary for 8DYF
Entry DOI | 10.2210/pdb8dyf/pdb |
Descriptor | Interleukin-17A, (5M)-3-[({2-[2-(2-{2-[2-({[(5M)-3-carboxy-5-(5,8-dihydroquinolin-4-yl)phenyl]amino}methyl)phenoxy]ethoxy}ethoxy)ethoxy]phenyl}methyl)amino]-5-(quinolin-4-yl)benzoic acid (3 entities in total) |
Functional Keywords | dimer, fragment, inhibitor, antagonist, cytokine |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 29931.65 |
Authors | Argiriadi, M.A.,Goedken, E.R. (deposition date: 2022-08-04, release date: 2022-09-07, Last modification date: 2023-10-18) |
Primary citation | Goedken, E.R.,Argiriadi, M.A.,Dietrich, J.D.,Petros, A.M.,Krishnan, N.,Panchal, S.C.,Qiu, W.,Wu, H.,Zhu, H.,Adams, A.M.,Bodelle, P.M.,Goguen, L.,Richardson, P.L.,Slivka, P.F.,Srikumaran, M.,Upadhyay, A.K.,Wu, B.,Judge, R.A.,Vasudevan, A.,Gopalakrishnan, S.M.,Cox, P.B.,Stoll, V.S.,Sun, C. Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12:14561-14561, 2022 Cited by PubMed: 36028520DOI: 10.1038/s41598-022-18760-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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