8DY1

Crystal Structure of scFv CAT2200 LH in complex with IL-17A

8DY1 の概要

• エントリーDOI: 10.2210/pdb8dy1/pdb
• 分子名称: Interleukin-17A, scFv CAT2200 LH, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: scfv, stapled scfv, spfv, germline scfv, single chain fv, scfv stabilizations, antibody, immune system, antibody antigen complex
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 82036.35

構造登録者

Luo, J.,Armstrong, A.A. (登録日: 2022-08-03, 公開日: 2023-05-03, 最終更新日: 2023-10-25)

• 主引用文献: Boucher, L.E.,Prinslow, E.G.,Feldkamp, M.,Yi, F.,Nanjunda, R.,Wu, S.J.,Liu, T.,Lacy, E.R.,Jacobs, S.,Kozlyuk, N.,Del Rosario, B.,Wu, B.,Aquino, P.,Davidson, R.C.,Heyne, S.,Mazzanti, N.,Testa, J.,Diem, M.D.,Gorre, E.,Mahan, A.,Nanda, H.,Gunawardena, H.P.,Gervais, A.,Armstrong, A.A.,Teplyakov, A.,Huang, C.,Zwolak, A.,Chowdhury, P.,Cheung, W.C.,Luo, J.; "Stapling" scFv for multispecific biotherapeutics of superior properties.; Mabs, 15:2195517-2195517, 2023; PubMed: 37074212; DOI: 10.1080/19420862.2023.2195517

実験手法

X-RAY DIFFRACTION (2.68 Å)