8DXS

Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein

8DXS の概要

• エントリーDOI: 10.2210/pdb8dxs/pdb
• EMDBエントリー: 27775
• 分子名称: Spike glycoprotein, P2B4 Heavy chain, P2B4 Light chain, ... (4 entities in total)
• 機能のキーワード: neutralizing antibody, fusion protein, spike glycoprotein, covid-19, rbd, rbd-directed antibody, p2b4, viral protein, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 578863.38

構造登録者

Reddem, E.R.,Shapiro, L. (登録日: 2022-08-03, 公開日: 2022-12-07, 最終更新日: 2023-01-18)

• 主引用文献: Luo, M.,Zhou, B.,Reddem, E.R.,Tang, B.,Chen, B.,Zhou, R.,Liu, H.,Liu, L.,Katsamba, P.S.,Au, K.K.,Man, H.O.,To, K.K.,Yuen, K.Y.,Shapiro, L.,Dang, S.,Ho, D.D.,Chen, Z.; Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.; Emerg Microbes Infect, 12:2146538-2146538, 2023; PubMed: 36354024; DOI: 10.1080/22221751.2022.2146538

実験手法

ELECTRON MICROSCOPY (3.76 Å)