8DXI

HIV-1 reverse transcriptase/rilpivirine with bound fragment [1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl]methanol at multiple sites

Summary for 8DXI

Entry DOI	10.2210/pdb8dxi/pdb
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (9 entities in total)
Functional Keywords	hiv-1 reverse transcriptase, transferase
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More
Total number of polymer chains	2
Total formula weight	115661.08
Authors	Chopra, A.,Ruiz, F.X.,Bauman, J.D.,Arnold, E. (deposition date: 2022-08-02, release date: 2023-05-31, Last modification date: 2023-10-25)
Primary citation	Chopra, A.,Bauman, J.D.,Ruiz, F.X.,Arnold, E. Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66:6013-6024, 2023 Cited by PubMed: 37115705 DOI: 10.1021/acs.jmedchem.2c01681 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation