8DXG
HIV-1 reverse transcriptase/rilpivirine with bound fragment 5-(trifluoromethyl)pyridin-2-ol at W24 site
Summary for 8DXG
Entry DOI | 10.2210/pdb8dxg/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 5-(trifluoromethyl)pyridin-2-one, ... (9 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, transferase |
Biological source | Human immunodeficiency virus type 1 BH10 More |
Total number of polymer chains | 2 |
Total formula weight | 115760.14 |
Authors | Chopra, A.,Ruiz, F.X.,Bauman, J.D.,Arnold, E. (deposition date: 2022-08-02, release date: 2023-05-31, Last modification date: 2023-10-25) |
Primary citation | Chopra, A.,Bauman, J.D.,Ruiz, F.X.,Arnold, E. Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. J.Med.Chem., 66:6013-6024, 2023 Cited by PubMed: 37115705DOI: 10.1021/acs.jmedchem.2c01681 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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