8DWG

CryoEM structure of Gq-coupled MRGPRX1 with peptide ligand BAM8-22 and positive allosteric modulator ML382

Summary for 8DWG

• Entry DOI: 10.2210/pdb8dwg/pdb
• Related: 8DWC
• EMDB information: 27753
• Descriptor: Proenkephalin-A, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 6
• Total formula weight: 139718.25

Authors

Liu, Y.,Cao, C.,Fay, J.F.,Roth, B.L. (deposition date: 2022-08-01, release date: 2022-11-02, Last modification date: 2023-04-12)

• Primary citation: Liu, Y.,Cao, C.,Huang, X.P.,Gumpper, R.H.,Rachman, M.M.,Shih, S.L.,Krumm, B.E.,Zhang, S.,Shoichet, B.K.,Fay, J.F.,Roth, B.L.; Ligand recognition and allosteric modulation of the human MRGPRX1 receptor.; Nat.Chem.Biol., 19:416-422, 2023; PubMed: 36302898; DOI: 10.1038/s41589-022-01173-6

Experimental method

ELECTRON MICROSCOPY (2.71 Å)