8DWG
CryoEM structure of Gq-coupled MRGPRX1 with peptide ligand BAM8-22 and positive allosteric modulator ML382
Summary for 8DWG
Entry DOI | 10.2210/pdb8dwg/pdb |
Related | 8DWC |
EMDB information | 27753 |
Descriptor | Proenkephalin-A, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | gpcr, signaling protein |
Biological source | Bos taurus (cattle) More |
Total number of polymer chains | 6 |
Total formula weight | 139718.25 |
Authors | Liu, Y.,Cao, C.,Fay, J.F.,Roth, B.L. (deposition date: 2022-08-01, release date: 2022-11-02, Last modification date: 2023-04-12) |
Primary citation | Liu, Y.,Cao, C.,Huang, X.P.,Gumpper, R.H.,Rachman, M.M.,Shih, S.L.,Krumm, B.E.,Zhang, S.,Shoichet, B.K.,Fay, J.F.,Roth, B.L. Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19:416-422, 2023 Cited by PubMed: 36302898DOI: 10.1038/s41589-022-01173-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.71 Å) |
Structure validation
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