8DW0
Glycosylase MutY variant N146S in complex with DNA containing d(8-oxo-G) paired with an enzyme-generated abasic site (AP) product and crystallized with sodium acetate
Summary for 8DW0
Entry DOI | 10.2210/pdb8dw0/pdb |
Related | 8DVP |
Descriptor | Adenine DNA glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*AP*(AAB)P*GP*TP*CP*T)-3'), ... (7 entities in total) |
Functional Keywords | protein-dna complex, dna repair, base excision repair, hydrolase, hydrolase-dna complex, hydrolase/dna |
Biological source | Geobacillus stearothermophilus More |
Total number of polymer chains | 3 |
Total formula weight | 48813.59 |
Authors | Demir, M.,Russelburg, L.P.,Horvath, M.P.,David, S.S. (deposition date: 2022-07-30, release date: 2022-11-30, Last modification date: 2023-10-25) |
Primary citation | Demir, M.,Russelburg, L.P.,Lin, W.J.,Trasvina-Arenas, C.H.,Huang, B.,Yuen, P.K.,Horvath, M.P.,David, S.S. Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism. Nucleic Acids Res., 51:1034-1049, 2023 Cited by PubMed: 36631987DOI: 10.1093/nar/gkac1246 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
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