8DVL

Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.18

8DVL の概要

• エントリーDOI: 10.2210/pdb8dvl/pdb
• 分子名称: Low-density lipoprotein receptor-related protein 6, E3.18 Disulfide constrained peptide, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: lrp6, e3e4, wnt signaling, signaling protein, disulfide constrained peptide, wnt agonism
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78247.60

構造登録者

Thakur, A.K.,Liau, N.P.D.,Sudhamsu, J.,Hannoush, R.N. (登録日: 2022-07-29, 公開日: 2023-03-29, 最終更新日: 2023-11-15)

• 主引用文献: Thakur, A.K.,Miller, S.E.,Liau, N.P.D.,Hwang, S.,Hansen, S.,de Sousa E Melo, F.,Sudhamsu, J.,Hannoush, R.N.; Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.; Acs Chem.Biol., 18:772-784, 2023; PubMed: 36893429; DOI: 10.1021/acschembio.2c00753

実験手法

X-RAY DIFFRACTION (2.5 Å)