8DVC

Receptor ShHTL5 from Striga hermonthica in complex with strigolactone agonist GR24

8DVC の概要

• エントリーDOI: 10.2210/pdb8dvc/pdb
• 関連するPDBエントリー: 5CBK 6DVA
• 分子名称: Hyposensitive to light 5, (3R,3aR,8bS)-3-({[(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methyl)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: striga hermonthica, strigolactone, signalling, receptor, shhtl5, alpha/beta hydrolase, signalling protein, receptor-agonist complex, signaling protein
• 由来する生物種: Striga hermonthica
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 153396.78

構造登録者

Arellano-Saab, A.,Skarina, T.,Yim, V.,Savchenko, A.,Stogios, P.J.,McCourt, P. (登録日: 2022-07-28, 公開日: 2023-06-14, 最終更新日: 2023-10-25)

主引用文献

Arellano-Saab, A.,Skarina, T.,Xu, Z.,McErlean, C.S.P.,Savchenko, A.,Lumba, S.,Stogios, P.J.,McCourt, P.
Structural analysis of a hormone-bound Striga strigolactone receptor.
Nat.Plants, 9:883-888, 2023

PubMed Abstract: Strigolactones (SLs) regulate many aspects of plant development, but ambiguities remain about how this hormone is perceived because SL-complexed receptor structures do not exist. We find that when SL binds the Striga receptor, ShHTL5, a series of conformational changes relative to the unbound state occur, but these events are not sufficient for signalling. Ligand-complexed receptors, however, form internal tunnels that posit an explanation for how SL exits its receptor after hydrolysis.

PubMed: 37264151
DOI: 10.1038/s41477-023-01423-y

実験手法

X-RAY DIFFRACTION (2.638 Å)